Publikationen/Publications
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Hamann A, Osiewacz HD (2022) To die or not to die - How mitochondrial processes affect lifespan of Podospora anserina. Biochim Biophys Acta Bioenerg 1863: 148568.
Hamann A, Osiewacz HD, Teichert I (2022) Sordaria macrospora sterile mutant pro34 is impaired in respiratory complex I assembly. J Fungi (Basel) 8: 1015.
Kleinw盲chter I, Mohr B, Joppe A, Hellmann N, Bereau T, Osiewacz HD, Schneider D (2022) CLiB - novel cardiolipin-binder isolated via data-driven in vitro screening. RSC Chem Biol 3: 941-954. doi: 10.1039/d2cb00125j
Marschall LM, Warnsmann V, Mee脽en AC, L枚ser T, Osiewacz HD (2022) Lifespan extension of Podospora anserina Mic60-subcomplex mutants depends on cardiolipin remodeling. Int J Mol Sci 23: 4741. doi: 10.3390/ijms23094741
Sch眉rmanns L, Hamann A, Osiewacz HD (2022) Lifespan increase of Podospora anserina by oleic acid is linked to alterations in energy metabolism, membrane trafficking and autophagy. Cells 11: 519. doi: 10.3390/cells11030519
Warnsmann V, Marschall
LM, Mee脽en AC, Wolters M, Sch眉rmanns L, Basoglu
M, Eimer S, Osiewacz HD (2022) Disruption of the MICOS complex leads to an aberrant cristae structure
and an unexpected, pronounced lifespan extension in Podospora anserina. J Cell Biochem 123: 1306-1326. doi: 10.1002/jcb.30278
Heinz D, Krotova E, Hamann A, Osiewacz HD (2021) Simultaneous ablation of the catalytic AMPK 伪-subunit SNF1 and mitochondrial matrix protease CLPP results in pronounced lifespan extension.
Klionsky DJ et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
L枚ser T, Joppe A, Hamann A, Osiewacz HD (2021) Mitochondrial phospholipid homeostasis is regulated by the i-AAA protease PaIAP and affects organismic aging.
Osiewacz HD, Sch眉rmanns L (2021) A network of pathways controlling cellular homeostasis affects the onset of senescence in Podospora anserina.
Warnsmann V, Marschall LM, Osiewacz HD (2021) Impaired F1F0-ATP-synthase dimerization leads to the induction of cyclophilin D- autophagy-dependent cell death and accelerated aging.
Warnsmann V, Meisterknecht J, Wittig I, Osiewacz HD (2021) Aging of Podospora anserina leads to alterations of OXPHOS and the induction of non-mitochondrial salvage pathways. Cells 10: 3319. doi: 10.3390/cells10123319
Gnaiger E et al. (2020) Mitochondrial physiology.
Henkel V, Sch眉rmanns L, Brunner M, Hamann A, Osiewacz HD (2020) Role of sorting nexin PaATG24 in autophagy, aging and development of Podospora anserina.
Koch I, Philipp O, Hamann A, Osiewacz HD (2020) Reconstruction of protein-protein interaction networks using homology-based search: Application to the autophagy pathway of aging in Podospora anserina.
Minina EA, Staal J, Alvarez VE, Berges JA, Berman-Frank I, Beyaert R, Bidle KD, Bornancin F, Casanova M, Cazzulo JJ, Choi JC, Coll NS, Dixit VM, Dolinar M, Fasel N, Funk C, Gallois P, Gevaert K, Gutierrez-Beltran E, Hailfinger S, Klemen膷i膷 M, Koonin EV, Krappmann D, Linusson A, Machado MFM, Madeo F, Megeney LA, Moschou PN, Mottram JC, Nystr枚m T, Osiewacz HD, Overall CM, Pandey KC, Ruland J, Salvesen GS, Shi Y, Smertenko A, Stael S, St氓hlberg J, Su谩rez MF, Thome M, Tuominen H, Van Breusegem F, Van der Horn RAL, Vardi A, Zhivotovsky B, Lam E, Bozhkov PV (2020) Classification and nomenclature of metacaspases and paracaspases: No more confusion with caspases.
Nguyen TD, Shaid S, Vakhrusheva O, Koshade SE, Klann K, Th枚lken M, Baker F, Zhang J, Oellerich T, S眉r眉n D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, M眉nch C, Dikic I, Brandts CH (2019) Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy.
Carmona-Gutierrez D et al. (2018) Guidelines and recommendations on yeast cell death nomenclature
Hamann A, Osiewacz HD (2018) Podospora anserina: a filamentous fungus with a strong mitochondrial etiology of aging. In: Ram JL, Conn M (eds) Handbook of models on human aging, 2nd Ed., Elsevier, pp 431-444
Meyer N, Zielke S, Michaelis JB, Lindner B, Warnsmann V, Rakel S, Osiewacz HD, Fulda S, Mittelbronn M, M眉nch C, Behrends C, K枚gel D (2018) AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. Autophagy 14: 1693-1709 (doi: 10.1080/15548627.2018.1476812)
Rampello NG, Strenger M, Westermann B, Osiewacz HD (2018) Impact of F1Fo-ATP-synthase dimer assembly factors on mitochondrial function and organismic aging.
Warnsmann V, Hainbuch S, Osiewacz HD (2018) Quercetin-induced lifespan extension in Podospora anserina requires methylation of the flavonoid by the O-methyltransferase PaMTH1.
Boilan E, Winant V, Dumortier E, ElMoualij B, Quatresooz P, Osiewacz HD, Debacq-Chainiaux, Toussaint O (2017) Role of prion protein in premature senescence of human fibroblasts.
Henkel V, Warnsmann V, Osiewacz HD (2017) Autophagic responses compensate mitochondrial impairments.
Knuppertz L, Osiewacz HD (2017) Autophagy compensates impaired energy metabolism in CLPXP deficient Podospora anserina strains and extends healthspan.
Knuppertz L, Warnsmann V, Hamann A, Grimm C, Osiewacz HD (2017) Stress-dependent opposing roles for mitophagy in aging of the ascomycete Podospora anserina.
Pampaloni F, Knuppertz L, Hamann A, Osiewacz HD, Stelzer EH (2017) Three-dimensial live imaging of filamentous fungi with light sheet-based fluorescence microscopy (LSM).
Philipp O, Hamann A, Osiewacz HD, Koch I (2017) The autophagy interaction network of the aging model Podospora anserina.
Warnsmann V, Meyer N, Hamann A, K枚gel D, Osiewacz HD (2017) A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction.
Klionsky DJ et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Knuppertz L, Osiewacz HD (2016) Orchestrating the network of molecular pathways affecting aging: Role of nonselective autophagy and mitophagy.
Kramer P, Jung A, Hamann A, Osiewacz HD (2016) Cyclophilin D is involved in the regulation of autophagy and affects the lifespan of P. anserina in response to mitochondrial oxidative stress.
Philipp O, Osiewacz HD, Koch I (2016) Path2PPI: an R package to predict protein-protein interaction networks for a set of proteins
Ramallo Guevara C, Philipp O, Hamann A, Werner A, Osiewacz HD, Rexroth S, R枚gner M, Poetsch A (2016) Global protein oxidation profiling suggests efficient mitochondrial proteasome homeostasis during ageing.
Warnsmann V, Hamann A, Osiewacz HD (2016) Im Alter z盲hlt jeder Zentimeter: Mitochondrien und biologisches Altern.
Warnsmann V, Osiewacz HD (2016) Curcumin treatment affects mitochondrial respiration, induces autophagy and increases lifespan of the fungal aging model Podospora anserina. Endocytobiosis and Cell Res 27: 20-26
Wiemer M, Grimm C, Osiewacz HD (2016) Molecular control of fungal senescence and longevity. In:
Bernhardt D, M眉ller M, Reichert A, Osiewacz HD (2015) Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan.
Chatterjee D, Kudlinzki D, Linhard V, Saxena K, Schieborr U, Gande SL, Wurm JP, W枚hnert J, Abele R, Rogov VV, D枚tsch V, Osiewacz HD, Sreeramulu S, Schwalbe H (2015) Structure and biophysical characterization of the S-adenosylmethionine-dependent O-methyltransferase PaMTH1, a putative enzyme accumulating during senescence of Podospora anserina.
Fischer F, Filippis C, Osiewacz HD (2015) RCF1-dependent respiratory supercomplexes are integral for lifespan-maintenance in a fungal ageing model.
Fischer F, Langer JD, Osiewacz HD (2015) Identification of potential mitochondrial CLPXP protease interactors and substrates suggests its central role in energy metabolism.
Grimm C, B枚hl L, Osiewacz HD (2015) Overexpression of Pa_1_10620 encoding a mitochondrial Podospora anserina protein with homology to superoxide dismutases and ribosomal proteins leads to lifespan extension.
Grimm C, Osiewacz HD (2015) Manganese rescues adverse effects on lifespan and development in Podospora anserina challenged by excess hydrogen peroxide.
Nystr枚m T, Kennedy B, Osiewacz HD (2015) Microbial models. In: Vijg J, J Campisi, G Lithgow G (eds) Molecular and Cellular Biology of Aging, GSA, GSA Press eBook. Web, Washington DC, pp 49-82
Osiewacz HD (2015) Mitochondria and bioenergetics. In: Vijg J, J Campisi, G Lithgow G (eds) Molecular and Cellular Biology of Aging, GSA, GSA Press eBook. Web, Washington DC, 432-458
Bernhardt D, Hamann A, Osiewacz HD (2014) The role of mitochondria in fungal aging.
Knuppertz L, Hamann A, Pampaloni F, Stelzer E, Osiewacz HD (2014) Identification of autophagy as a longevity-assurance mechanism in the aging model Podospora anserina. )
Plohnke N, Hamann A, Poetsch A, Osiewacz HD, R枚gner M, Rexroth S (2014) Proteomic analysis of mitochondria from senescent Podospora anserina casts new light on ROS dependent aging mechanisms.
Wiemer M, Osiewacz HD (2014a) The proteasome activity reporter GFP-CI1 is degraded by autophagy in the aging model Podospora anserina.
Wiemer M, Osiewacz HD (2014b) Effect of paraquat-induced oxidative stress on gene expression and aging of the filamentous ascomycete Podospora anserina casts new light on ROS dependent aging mechanisms.
Boilan E, Winant V, Dumortier E, Piret JP, Bonfitto F, Osiewacz HD, Debacq-Chainiaux F, Toussaint O (2013) Role of p38MAPD and oxidative stress in copper-induced senescence.
Chimi MA, Dr枚se S, Wittig I, Heide H, Steger M, Werner A, Hamann A, Osiewacz HD, Brandt U (2013) Age-related changes in the mitochondrial proteome of the fungus Podospora anserina analyzed by 2D-DIGE and LC-MS/MS.
Daum B, Walter A, Horst A, Osiewacz HD, K眉hlbrandt W (2013) Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria.
Figge MT, Osiewacz HD, Reichert AS (2013) Quality control of mitochondria during aging: Is there a good and a bad side of mitochondrial dynamics? .
Fischer F, Weil A, Hamann A, Osiewacz HD (2013) Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain. .
Gispert S, Parganlija D, Klinkenberg M, Dr枚se S, Wittig I, Mittelbronn M, Grzmil P, Koob S, Hamann A, Walter M, B眉chel F, Adler T, Hrab茅 de Angelis M, Busch DH, Zell A, Reichert AS, Brandt U, Osiewacz HD, Jendrach M, Auburger G (2013) Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Osiewacz HD, Bernhardt D (2013) Mitochondrial quality control: impact on aging and life span.
Osiewacz HD, Hamann A, Zintel S (2013) Assessing organismal aging in the filamentous fungus Podospora anserina. In: Galuzzi L et al (eds) Cell Senescence: Methods and Protocols.
Philipp O, Hamann A, Servos J, Werner A, Koch I, Osiewacz HD (2013) A genome-wide longitudinal transcriptome analysis of the aging model Podospora anserina.
Strobel I, Osiewacz HD (2013) Poly(ADP-ribose) polymerase is a substrate recognized by two metacaspases of Podospora anserina.
Figge MT, Reichert A, Meyer-Hermann M, Osiewacz HD (2012) Deceleration of fusion-fission cycles improves mitochondrial quality control during aging. .
Fischer F, Hamann A, Osiewacz HD (2012) Mitochondrial quality control: an integrated network of pathways. .
Kowald A, Hamann A, Zintel S, Ullrich S, Klipp E, Osiewacz HD (2012) A systems biological analysis links ROS metabolism to mitochondrial protein quality control. .
Osiewacz HD, Scheckhuber CQ (2012) The basis of biological aging: Theories, models and mechanisms.In: Alt KW, de Jong W, R枚der B (eds) Alter(n) anders denken. Kulturelle und biologische Perspektiven. B枚hlau Verlag, K枚ln, Weimar, Wien, 359-369.
Scheckhuber CQ, Hamann A, Brust D, Osiewacz HD (2012) Cellular homeostasis in fungi: impact on the aging process. .
Servos J, Hamann A, Grimm C, Osiewacz HD (2012) A differential genome-wide transcriptome analysis: Impact of cellular copper on complex biological processes like aging and development. .
Rexroth S, Poetsch A, R枚gner M, Hamann A, Werner A, Osiewacz HD, Sch盲fer ER, Seelert H, Dencher NA (2012) Reactive oxygen species target specific tryptophan site in the mitochondrial ATP synthase. .
Davies KM, Strauss M, Daum B, Kief JH, Osiewacz HD, Rycovska A, Zickermann V, K眉hlbrandt W (2011) Macromolecular organization of ATP synthase and complex I in whole mitochondria. .
M眉ller-Ohldach M, Brust D, Hamann A, Osiewacz HD (2011) Overexpression of PaParp encoding the poly(ADP-ribose) polymerase of Podospora anserina affects organismal aging. .
Osiewacz HD (2011) Mitochondrial quality control in aging and lifespan control of the fungal aging model Podospora anserina. .
Scheckhuber CQ, Houthoofd K, Weil AC, Werner A, De Vreese A, Vanfleteren JR, Osiewacz HD (2011) Alternative oxidase dependent respiration leads to an increased mitochondrial content in two long-lived mutants of the ageing model Podospora anserina. .
Scheckhuber CQ, Wanger RA, Mignat CA, Osiewacz HD (2011) Unopposed mitochondrial fission leads to severe lifespan shortening. .
Weil A , Luce K, Dr枚se S, Wittig I, Brandt U, Osiewacz HD (2011) Unmasking a temperature-dependent effect of the P. anserina i-AAA protease on aging and development. .
Zintel S, Bernhardt D, Rogowska-Wrzesinska A, Osiewacz HD (2011) PaCATB, a secreted catalase protecting Podospora anserina against exogenous oxidative stress. .
Blagosklonny MV., Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM. Jr, Brunet A, DePinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkow AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J (2010) Impact papers on aging in 2009. .
Brust D, Daum B, Breunig C, Hamann A, K眉hlbrandt W, Osiewacz HD (2010) Cyclophilin D links programmed cell death and organismal aging in Podospora anserina. .
Brust D, Hamann A, Osiewacz HD (2010) Deletion of PaAif2 and PaAmid2, two genes encoding mitochondrial AIF-like oxidoreductases of Podospora anserina, leads to increased stress tolerance and lifespan extension. .
Knab B, Osiewacz HD (2010) Methylation of polyphenols with vicinal hydroxyl groups: A protection pathway increasing organismal lifespan. .
Luce K, Weil AC, Osiewacz HD (2010) Mitochondrial protein quality control systems in aging and disease. In: Tavernarakis N (ed) Protein metabolism and homeostasis in aging. .
M眉ller-Ohldach M, Brust D, Hamann A, Osiewacz HD (2010) Overexpression of PaParp encoding the poly(ADP-ribose) polymerase of Podospora anserina affects organismal aging. .
Nowrousian M, Stajich JE, Chu M, Engh I, Espagne E, Halliday K, Kamerewerd J, Kempken F, Knab B, Kuo HC, Osiewacz HD, P枚ggeler S, Read ND, Seiler S, Smith KM, Zickler D, K眉ck U, Freitag M (2010) De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis. .
Osiewacz HD (2010) Role of mitochondria in aging and age-related disease. .
Osiewacz HD, Brust D, Hamann A, Kunstmann B, Luce K, M眉ller-Ohldach M, Scheckhuber CQ, Servos J, Strobel I (2010) Mitochondrial pathways governing stress resistance, life, and death in the fungal aging model Podospora anserina. .
Scheckhuber CQ, Mack SJ, Strobel I, Ricciardi F, Gispert S, Osiewacz HD (2010) Modulation of the glyoxalase system in the aging model Podospora anserina: effects on growth and lifespan. .
Zintel S, Schwitalla D, Luce K, Hamann A, Osiewacz HD (2010) Increasing mitochondrial superoxide dismutase abundance leads to impairments in protein quality control and ROS scavenging systems and to lifespan shortening. .
Hamann A, Osiewacz HD (2009) Apoptose - Programmierter Zelltod im Reich der Pilze.
Kunstmann B, Osiewacz HD (2009) The S-adenosylmethionine dependent O-methyltransferase PaMTH1: a longevity assurance factor protecting Podospora anserina against oxidative stress. .
Luce K, Osiewacz HD (2009) Increasing organismal healthspan by enhancing mitochondrial protein quality control. .
Scheckhuber CQ (2009) Impact of mitochondrial dynamics on organismic aging. .
Scheckhuber CQ, Grief J, Boilan E, Luce K, Debacq-Chainiaux F, Rittmeyer C, Gredilla R, Kolbesen BO, Toussaint O, Osiewacz HD (2009) Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts. .
Scheckhuber CQ, Mitterbauer R, Osiewacz HD (2009) Molecular basis of and interference into degenerative processes in fungi: potential relevance for improving biotechnological performance of microorganisms. .
Soerensen M, Gredilla R, M眉ller-Ohldach M, Werner A, Bohr VA, Osiewacz HD, Stevnsner T (2009) A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserina: decrease in mitochondrial DNA repair activity during ageing. .
Strobel I, Breitenbach J, Scheckhuber CQ, Osiewacz HD, Sandmann G (2009) Carotenoids and carotenogenic genes in Podospora anserina: engineering of the carotenoid composition extends the life span of the mycelium. .
Hamann A, Brust D, Osiewacz HD (2008) Apoptosis pathways in fungal growth, development and ageing. .
Kunstmann B, Osiewacz HD (2008) Over-expression of an S-adenosylmethionine-dependent methyltransferase leads to an extended life span of Podospora anserina without impairments in vital functions. .
Osiewacz HD, Scheckhuber CQ (2008) Reactive oxygen species in molecular pathways controlling aging in the filamentous fungus Podospora anserina. In: Miwa S, Beckman KB, Muller FL (eds) Oxidative Stress in Aging. From Model Systems to Human Diseases. Humana Press, Totowa: 53-65.
Scheckhuber CQ, Osiewacz HD (2008) Podospora anserina - A model organism to study mechanisms of healthy ageing. .
Scheckhuber CQ, R枚del E, W眉stehube J (2008) Regulation of mitochondrial dynamics - characterization of fusion and fission genes in the ascomycete Podospora anserina. .
Groebe K, Krause F, Kunstmann B, Unterluggauer H, Reifschneider NH, Scheckhuber CQ, Sastri C, Stegmann W, Wozny W, Schwall GP, Poznanovic S, Dencher NA, Jansen-D眉rr P, Osiewacz HD, Schrattenholz A (2007) Differential proteomic profiling of mitochondria from Podospora anserina, rat and human reveals distinct patterns of age-related oxidative changes. .
Hamann A, Brust D, Osiewacz HD (2007) Deletion of putative apoptosis factors leads to lifespan extension in the fungal ageing model Podospora anserina. .
Scheckhuber CQ, Erjavec N, Tinazli A, Hamann, A, Nystr枚m T, Osiewacz HD (2007) Reducing mitochondrial fission results in increased lifespan and fitness of two fungal ageing models. .
Gredilla R, Grief J, Osiewacz HD (2006) Mitochondrial free radical generation and lifespan control in the fungal aging model Podospora anserina. .
Hunzinger C, Wozny W, Schwall GP, Poznanovic S, Stegmann W, Zengerling H, Schoepf R, Groebe K, Cahill MA, Osiewacz HD, J盲gemann N, Bloch M, Dencher NA, Krause F Schrattenholz A (2006) Comparative profiling of the mammalian mitochondrial proteome: multiple aconitase-2 isoforms including N-formylkynurenine modifications as part of a protein biomarker signature for reactive oxidative species. .
Krause F, Scheckhuber CQ, Werner A, Rexroth S, Reifschneider NH, Dencher NA, Osiewacz HD (2006) OXPHOS supercomplexes: Respiration and life-span control in the aging model Podospora anserina. .
Osiewacz HD, Scheckhuber CQ (2006) Impact of ROS on ageing of two fungal model systems: Saccharomyces cerevisiae and Podospora anserina. .
Hamann A, Krause K, Werner A, Osiewacz HD (2005) A two-step protocol for efficient deletion of genes in the filamentous ascomycete Podospora anserina. .
Hamann A, Osiewacz HD (2004) Genetic analysis of spore killing in the filamentous ascomycete Podospora anserina. .
Krause F, Scheckhuber CQ, Werner A, Rexroth S, Reifschneider NH, Dencher NA, Osiewacz HD (2004) Supramolecular organization of COX- and AOX-dependent respiratory chains in the filamentous fungus Podospora anserina. .
Osiewacz HD (2004) Aging and mitochondrial dysfunction in the filamentous fungus Podospora anserina. In: Nystr枚m T, Osiewacz HD (eds.): Model systems in ageing. Springer, Heidelberg, New York, Tokyo, pp 17-38.
Osiewacz HD, Hamann A (2004) Senescence and longevity. In: K眉es U, Fischer R (Vol. eds.): The Mycota I, 2nd Edition. Springer, Heidelberg, New York, Tokyo, pp 189-200.
Stumpferl SW, Stephan O, Osiewacz HD (2004) Impact of a disruption of a pathway delivering copper to mitochondria on Podospora anserina . .
Osiewacz HD (2003) Ageing and longevity in the filamentous fungus Podospora anserina. In: Osiewacz HD (Volume Editor): Aging of the organisms. Kluwer Academic Publisher, Dordrecht, The Netherlands, pp 31-53.
Borghouts C, Scheckhuber CQ, Stephan O, Osiewacz HD (2002) Copper homeostasis and aging in the fungal model system Podospora anserina: differential expression of PaCtr3 encoding a copper transporter. .
Borghouts C, Scheckhuber CQ, Werner A, Osiewacz HD (2002) Respiration, copper availability and SOD activity in Podospora anserina strains with different lifespan. .
Osiewacz HD (2002a) Genes, mitochondria and aging in filamentous fungi. .
Osiewacz HD (2002b) Aging in fungi: role of mitochondria in Podospora anserina. .
Osiewacz HD (2002c) Mitochondrial functions and aging. .
Osiewacz HD, Scheckhuber CQ (2002) Senescence in Podospora anserina. In: Osiewacz HD (ed.) Molecular Biology of Fungal Development. Marcel Dekker, New York, pp 87-108.
Averbeck N, Borghouts C, Hamann A, Specke V, Osiewacz HD(2001) Molecular control of copper homeostasis in filamentous fungi: increased expression of a metallothionein gene during aging of Podospora anserina. .
Borghouts C, Werner A, Elthon T, Osiewacz HD (2001) Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina. .
Osiewacz HD, Stumpferl SW (2001) Metabolism and aging in the filamentous fungus Podospora anserina. .
Averbeck N, Jensen ON, Mann M, Sch盲gger H, Osiewacz HD (2000) Identification and characterization of PaMTH1, a putative O-methyltransferase accumulating during senescence of Podospora anserina cultures. .
Borghouts C, Kerschner S, Osiewacz HD (2000) Copper-dependence of mitochondrial DNA rearrangements in Podospora anserina. .
Borghouts C, Osiewacz HD (2000) Nuclear-mitochondrial interactions involved in aging in Podospora anserina. .
Hamann A, Feller F, Osiewacz HD (2000a) The degenerate DNA transposon Pat and repeat-induced point mutation (RIP) in Podospora anserina . .
Hamann A, Feller F, Osiewacz HD (2000b) Yeti 鈥� a degenerate gypsy-like LTR retrotransposon in the filamentous ascomycete Podospora anserina . .
Osiewacz HD (2000) The genetic basis of aging in the fungal aging model Podospora anserina. Futura 15: 237-241.
Osiewacz HD, Borghouts C (2000a) Mitochondrial oxidative stress and aging in the filamentous fungus Podospora anserina. In: Toussaint O, Osiewacz HD, Lithgow G, Brack C (eds): Molecular and Cellular Gerontology. Ann NY Acad Sci 908, 31-39.
Osiewacz HD, Borghouts C (2000b) Cellular Copper homeostasis, mitochondrial DNA instabilities, and lifespan control in the filamentous fungus Podospora anserina. .
Khashnobish A, Hamann A, Osiewacz HD (1999) Modulation of gene expression by (CA)n microsatellites in the filamentous fungus Podospora anserina. .
Kimpel E, Osiewacz HD (1999) PaGrg1 , a glucose repressible gene of Podospora anserina that is differentially expressed during lifespan. .
Osiewacz HD (1999) Fondamenti genetici dell'invecchiamento biologico. In: Colantonio R, Lucchetti M, Venturelli A (eds).Ambiente e invecchiamento. Politiche e strategie di ricerca in Germania e in Italia.Edizioni Angelo Guerini e Associati SpA. Mailand, pp 117-125.
Osiewacz HD, Kimpel E (1999) Mitochondrial-nuclear interactions and lifespan control in fungi. .
Borghouts C, Osiewacz HD (1998) GRISEA, a copper-modulated transcription factor of Podospora anserina involved in senescence and morphogenesis, is an ortholog of MAC1 in Saccharomyces cerevisiae ..
Hamann A, Osiewacz HD (1998) Genome analysis of filamentous fungi: Identification and characterization of an unusual GT-rich minisatellite in the ascomycete Podospora anserina . .
van der Gaag M, Debets AJM, Osiewacz HD, Hoekstra RF (1998) The dynamics of pAL2-1 homologous linear plasmids Podospora anserina . .
Borghouts C, Kimpel E, Osiewacz HD (1997) Mitochondrial DNA rearrangements of Podospora anserina are under the control of the nuclear gene grisea . .Osiewacz HD (1997) Genetic regulation of aging. .
Osiewacz HD, Hamann A (1997) DNA reorganization and biological aging. A review. .
P枚ggeler S, Risch S, K眉ck U, Osiewacz HD (1997) Mating-type genes from the homothallic fungus Sordaria macrospora are functionally expressed in a heterothallic ascomycete. .
Hermanns J, Osiewacz HD (1996) Induction of longevity by cytoplasmic transfer of a linear plasmid in Podospora anserina . .
Osiewacz HD (1996a) Extrachromosomal and transposable genetic elements. In: Bos CJ (ed) Fungal Genetics . Marcel Dekker, New York, pp 177-208.
Osiewacz HD (1996b) Genetic analysis of senescence in Podospora anserina . In: Bos CJ (ed) Fungal Genetics . Marcel Dekker, New York, pp 317-335.
Osiewacz HD (1996c) Nuclear-mitochondrial interactions involved in biological aging. In: Rattan SIS, Toussaint O (eds) Molecular Gerontology, Plenum Press, New York, pp 37-52.
Osiewacz HD, Hamann A, Werner A (1996) Genome analysis of filamentous fungi: identification of a highly conserved simple repetitive sequence in different strains of Podospora anserina . .
Osiewacz HD, Nuber U (1996) GRISEA, a putative copper-activated transcription factor of Podospora anserina involved in differentiation and senescence. .
Schwartz T, Osiewacz HD (1996) Telomere length does not change during senescence of the ascomycete Podospora anserina . .
Hermanns J, Asseburg A, Osiewacz HD (1995) Evidence for giant linear plasmids in the ascomycete Podospora anserina . .
Hermanns J, Debets F, Hoekstra R, Osiewacz HD (1995) A novel family of linear plasmids. .
Johnson T, Arking R, Bertrand H, Driscoll M, Esser K, Griffiths A, Harley C, Jazwinski SM, Kirkwood T, Osiewacz (1995) Research on diverse model systems and the genetic basis of aging and longevity. In: Esser K, Martin GM (eds) Molecular Aspects of Aging , Wiley & Sons, Chichester, pp 62-76.
Osiewacz HD (1995a) Aging and genetic instabilities. In: Esser K, Martin GM (eds) Molecular Aspects of Aging.Wiley & Sons, Chichester, pp 29-44.
Osiewacz HD (1995b) Molekulare Mechanismen biologischen Alterns. .
B眉rkle A, Osiewacz HD (1994) Altern von makromolekularen Substanzen der Zelle - Nukleins盲uren. In: Olbrich E, Sames K, Schramm A (eds) Kompendium der Gerontologie. Ecomed Verlag, Landsberg, Kap. IV - 2.1.2.1: 1-9.
Hermanns J, Asseburg A, Osiewacz HD (1994) Evidence for a life span-prolonging effect of a linear plasmid in a longevity mutant of Podospora anserina. .
Hermanns J, Osiewacz HD (1994) Three mitochondrial unassigned open reading frames of Podospora anserina represent remnants of a viral-type RNA polymerase gene. .
Kruip J, Nixon PJ, Osiewacz HD, R枚gner M (1994) Nucleotide sequence of the petB gene encoding cytochrome b6 from the mesophilic cyanobacterium Synechocystis PCC 6803: implications for evolution and function. .
Osiewacz HD (1994a) Auf der Suche nach den Alternsgenen. Einblick 4: 10-13.
Osiewacz HD (1994b) Biologisches Altern und mitochondriale DNA-Instabilit盲ten. Bioscope 2: 21-28.
Osiewacz HD (1994c) Modellsysteme in der experimentellen Alternsforschung. In: Neises M, Wischnik A, Melchert F (eds) Der Geriatrische Tumorpatient.Karger, Basel Freiburg Paris London New York New Delhi Bangkok Singapore Tokyo Sidney: 25-32.
Osiewacz HD (1994d) A versatile shuttle cosmid vector for the efficient construction of genomic libraries and for the cloning of fungal genes. .
Mohamed A, Eriksson J, Osiewacz HD, Jansson C (1993) Differential expression of the psbA genes in the cyanobacterium Synechocystis 6803. .
Osiewacz HD (1993) Fungi as model systems in experimental gerontolology.In: Deutsches Krebsforschungszentrum (ed) Current Cancer Research 1992. Steinkopff-Verlag, Darmstadt, Springer-Verlag, New York: 147-151.
Hermanns J, Osiewacz HD (1992) The linear mitochondrial plasmid pAL2-1 of a long-lived Podospora anserina mutant is an invertron encoding a DNA and RNA polymerase. .
Kempken F, Hermanns J, Osiewacz HD (1992) Evolution of linear plasmids. .
Osiewacz HD (1992a) Genetic control of aging in the ascomycete Podospora anserina. In: Zwilling R, Balduini C (eds) Biology of Aging. Springer-Verlag, Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest: 153-164.
Osiewacz HD (1992b) Experimentelle Alternsforschung - Pilze als Modellsysteme. In: Deutsches Krebsforschungszentrum (ed) Krebsforschung heute. Steinkopff-Verlag, Darmstadt: 165-170.
Osiewacz HD (1992c) Construction of insertion mutants of Synechocystis sp. PCC 6803: evidence for an essential function of subunit IV of the cytochrome b6/f complex. .
Osiewacz HD, Hermanns J (1992) The role of mitochondrial DNA rearrangements in aging and human diseases. .
Ridder R, Osiewacz HD (1992) Sequence analysis of the gene coding for glyceraldehyde-3-phosphate dehydrogenase (gpd) of Podospora anserina: use of homologous regulatory sequences to improve transformation efficiency. .
Gurevitz M, Osiewacz HD, Keren Y (1991) Molecular evidence for interchromosomal recombination in the cyanobacterium Synechocystis sp. PCC 6803. .
Osiewacz HD, Ridder R (1991) Genome analysis of imperfect fungi: electrophoretic karyotyping and characterization of the nuclear gene coding for glyceraldehyde-3-phosphate dehydrogenase (gpd) of Curvularia lunata. .
Osiewacz HD, Skaletz A, Esser K (1991) Integrative transformation of the ascomycete Podospora anserina: identification of the mating-type locus on chromosome VII of electrophoretically separated chromosomes. .
Ridder R, K眉nkele K-P, Osiewacz HD (1991) Sequence of the nuclear ATP synthase subunit 9 gene of Podospora anserina: lack of similarity to the mitochondrial genome. .
Osiewacz HD (1990) Molecular analysis of aging processes in fungi. .
Osiewacz HD, Clairmont A, Huth M (1990) Electrophoretic karyotype of the ascomycete Podospora anserina. .
Osiewacz HD, Heinen U (1989) Recombination of mobile genetic elements from plants and cyanobacteria. Prog Bot 50: 174-197.
Osiewacz HD, Hermanns J, Marcou D, Triffi M, Esser K (1989) Mitochondrial DNA rearrangements are correlated with a delayed amplification of the mobile intron (plDNA) in a long-lived mutant of Podospora anserina. .
Osiewacz HD, Weber A (1989) DNA mediated transformation of the filamentous fungus Curvularia lunata using a dominant selectable marker. .
Jansson C, Debus RJ, Osiewacz HD, Gurevitz M, McIntosh L (1987) Construction of an obligate photoheterotrophic mutant of the cyanobacterium Synechocystis 6803: inactivation of the psbA gene family. .
Osiewacz HD, McIntosh L (1987) Nucleotide sequence of a member of the psbA multigene family from the unicellular cyanobacterium Synechocystis 6803. .
B枚ckelmann B, Osiewacz HD, Schmidt FR, Schulte E (1986) Extrachromosomal DNA in fungi-organization and function. In: Buck KW (ed) Fungal Virology.CRC Press, Boca Raton, Florida: 237-283.
Osiewacz HD (1986) Recombination in cyanobacteria and lower plants after vector-mediated DNA transfer. Prog Bot 48: 224-240.
K眉ck U, Osiewacz HD, Schmidt U, Kappelhoff B, Schulte E, Stahl U, Esser K (1985) The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina. .
Osiewacz HD, Esser K (1984) The mitochondrial plasmid of Podospora anserina: a mobile intron of a mitochondrial gene. .
Osiewacz HD, Esser K (1983) DNA sequence analysis of the mitochondrial plasmid of Podospora anserina. .
Osiewacz HD (Volume Editor) (2014) Progress in Molecular Biology and Translational Science, Volume 127: The Mitochondrion in Aging and Disease. Academic Press, Amsterdam, Heidelberg.
Nystr枚m T, Osiewacz HD (Volume Editors) (2004) Model Systems in Aging. Springer, Heidelberg New York, Tokyo.
Osiewacz HD (Volume Editor) (2003) Aging of Organisms. Kluwer Academic Publisher, Dordrecht.
Osiewacz HD (Volume Editor) (2002 a) Molecular Biology of Fungal Development. Marcel Dekker, New York.
Osiewacz HD (Volume Editor) (2002b) The Mycota, Volume X: Industrial Applications. Springer, Heidelberg New York Tokyo
Toussaint O, Osiewacz HD, Lithgow G, Brack C (eds) (2000) Molecular and Cellular Gerontology. Ann. N.Y. Acad. Sci., 908.
Esser K, K眉ck U, Lang-Hinrichs C, Lemke P, Osiewacz HD, Stahl U, Tudzynski P (1986) Plasmids of eukaryotes. Fundamentals and applications. Springer Science Library. Springer, Heidelberg New York Tokyo
Osiewacz HD (1984): Mitochondriale Mosaikgene: Strukturaufkl盲rung eines mobilen Introns aus dem Ascomyceten Podospora anserina. Bibliotheca Mycologica Bd. 94. Cramer, Vaduz
Scheckhuber C, Osiewacz HD (2006) The Role of Mitochondria in Conserved Mechanisms of Aging. .
Scheckhuber C (2005a) Mitochondrial Dynamics in Cell Life and Death. .
Scheckhuber C (2005b) Report on the 14th Annual Meeting of the German Society for Geriatric Research. .
Scheckhuber C, Osiewacz HD (2005) MiMage: a pan-European project on the role of mitochondria in aging. .
Jansen-D眉rr P, Osiewacz HD (2002) Healthy ageing: a question of stress, damage and repair: Meeting on mechanisms on biological ageing. .
Brack C, Lithgow G, Osiewacz H, Toussaint O (2000) EMBO Workshop Report: Molecular and cellular gerontology, Serpiano, Switzerland, September 17-22, 1999, .